Reaction ID:0000000003
Reactant:100.00 eq. N N N O O N S F F O O O F - OBDepict
InChiInChI=1S/C14H11F3N4O5S/c1-25-13-18-10(19-14(20-13)26-2)8-6-4-3-5-7(15)9(6)21(11(8)22)27(23,24)12(16)17/h3-5,8,12H,1-2H3
Name1-[(difluoromethyl)sulfonyl]-3-(4,6-dimethoxy-1,3,5-triazone-2-yl)-7-fluoro-1H-indol-2-ol
Ligand:5.00 eq. N O O H - OBDepict
NamePicolinic acid
Catalyst:5.00 eq. iron(II) sulfate heptahydrate
Base:100.00 eq. Potassium bicarbonate
Oxidizing agent:700.00 eq. O O H H - OBDepict
Namehydrogen peroxide
Temperature25 °C
Reaction time170 min.
Solvent:999.99 eq. N - OBDepict
Nameacetonitrile
Solvent:999.99 eq. OH 2 - OBDepict
Namewater
Product:90.00 eq. N N N O O O F N H S F F O O - OBDepict
NameN-{2-[(4,6-dimethoxy-1,3,5-triazine-2-yl)carbonyl]-6-fluorophenyl}-1,1-difluormethanesulfonamide
InChiInChI=1S/C13H11F3N4O5S/c1-24-12-17-10(18-13(19-12)25-2)9(21)6-4-3-5-7(14)8(6)20-26(22,23)11(15)16/h3-5,11,20H,1-2H3
DOI
PatentWO2012084857
URLlink
Reaction type:functional group oxidation